Insight imaging
Please review the source and remedy this by editing this article to remove any non-free copyrighted content and attributing free content correctly, or flagging the content for deletion. This article or section may have been copied and pasted from another location, possibly in violation of Wikipedia's copyright policy. In the long perspective, this could potentially allow to study functional neuroactivation on a single-patient level and thus bring functional neuroimaging to clinical diagnostics. Functional neuroimaging using MPI has been successfully demonstrated in rodents and has a promising sensitivity advantage compared to other imaging modalities. For this, MPI is used to detect the increase of cerebral blood volume (CBV) arising from neuroactivation. MPI has been proposed as a promising platform for functional brain imaging which requires highly sensitive imaging as well as short scan times for sufficient temporal resolution. The tracer is stable while tagged to a cell and remains detectable past 87 days. Imaging can be used to improve the success of stem cell therapy by following the movement of these cells in the body. This has applications in regenerative medicine and cancer immunotherapy. MPI is being investigated as a clinical alternative screening technique to nuclear medicine in order to reduce radiation exposure in at-risk populations.īy tagging therapeutic cells with iron oxide nanoparticles, MPI allows them to tracked throughout the body. The high sensitivity of the technique means it may also be possible to image micro-metastasis through the development of nanoparticles targeted to cancer cells. This has been successfully used to detect tumor sites within rats. Accumulation of a tracer within solid tumors can occur through the enhanced permeability and retention effect. MPI has numerous applications to the field of oncology research. With further research, this could eventually be used for real-time cardiac imaging. The first in vivo MPI results provided images of a beating mouse heart in 2009. SPIOs have previously been used in humans for iron supplementation and liver imaging.īlood pool imaging Cardiovascular The iron oxide nanoparticles are broken down in the liver, where the iron is stored and used to produce hemoglobin. The iron oxide tracer used with MPI are cleared naturally by the body through the mononuclear phagocyte system. Imaging is performed in a range of milliseconds to seconds. Magnetic particle imaging combines high tracer sensitivity with submillimeter resolution. MPI is often used in combination with anatomical imaging techniques (such as CT or MRI) providing information on the location of the tracer. Since there is no natural SPIO in tissue, a signal is only detected from the administered tracer. An image is generated by moving this region across a sample. A signal is only generated in this region. These fields are specifically designed to produce a single magnetic field free region.
MPI systems use changing magnetic fields to generate a signal from superparamagnetic iron oxide (SPIO) nanoparticles. The hardware used for MPI is very different from MRI. The first commercial MPI scanners have recently become available from Magnetic Insight and Bruker Biospin.
Since then, the technology has been advanced by academic researchers at several universities around the world. The first system was established and reported in 2005. MPI was first conceived in 2001 by scientists working at the Royal Philips Research lab in Hamburg. Imaging does not use ionizing radiation and can produce a signal at any depth within the body. Currently, it is used in medical research to measure the 3-D location and concentration of nanoparticles. The technology has potential applications in diagnostic imaging and material science. Magnetic particle imaging ( MPI) is an emerging non-invasive tomographic technique that directly detects superparamagnetic nanoparticle tracers.